12/25/2023 0 Comments Elucidate the mechanims![]() It is expected that NIH HEAL Initiative recipients will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings, including an annual HEAL Investigators Meeting, as well as other activities. The NIH HEAL Initiative will require a high level of coordination and sharing between investigators. More information about the HEAL Initiative is available at. The NIH HEAL Initiative bolsters research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. This funding announcement is part of the NIH’s Helping to End Addiction Long-term (HEAL) Initiative to speed scientific solutions to the national opioid public health crisis. Teams are encouraged to consider objectives that will produce major advances in the understanding of device-based pain relief that are likely to improve strategies for pain management. Project goals should not be achievable with a collection of individual efforts or projects. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. ![]() Program teams are expected to accomplish goals that require considerable synergy and collaborative interactions. This funding opportunity announcement (FOA) is designed to support interdisciplinary research teams of multiple PD/PIs to investigate the mechanisms of action of pain relief using FDA-approved or -cleared medical devices with the overall goal of optimizing therapeutic outcomes for these technologies. Through targeted research efforts, the NIH HEAL Initiative aims to support the development of safe and effective devices to treat pain with little or no addiction liability. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. This is certainly obvious for homonyms: words which are spelled and/or pronounced the same way, but have different definitions.More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. The way that language is learned is heavily derived via context clues. The key to understanding what individual words mean often can be found in the terms around the target term. ![]() What's Special About Example Sentences of 'Elucidate'? This is especially true when idioms are used routinely in everyday writing. It is important for non-native speakers of a language to gain familiarity with idioms, so that they are not confused. It is also difficult to ascertain the meaning of idiom phrases since they can only be learned within the language you’re attempting to learn. Instead, it is an expression illustrating the severity of the rain. Example: It’s raining cats and dogs today in the English language does not literally mean it’s raining dogs and cats from the sky. In most cases, idiom phrases are language-specific and cannot be simply translated and used in another language without the context and meaning being distorted. Idioms are clauses whose definition is not constructed from the literal expression.
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